Oxytocin Measures
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Oxytocin Measures
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About Us

Pregnant woman floating in the water

We are midwives asking questions about Post-Partum Haemorrhage (PPH rates), critiquing, analysing oxytocin guidelines and policies for induction and augmentation of labour. `We teach and inform women, their birth partners and professionals about synthetic oxytocin induction and augmentation of labour.


We are also reviewing and rethinking synthetic oxytocin practice in view of licensed and off-licensed (unlicensed) dilution and dosages and its impact on the woman giving birth, the baby and postnatal outcomes. This pain inducing hormone requires deeper investigation and scrutiny into current practice across the UK and globally.


Further discussion with women, their partners, midwives and obstetricians with reference to consent, regimes, and outcomes of women and their babies is needed.

Frequently asked questions

Here are some of the questions that we have asked, please contact us for further detailed information or help with your regime or guideline.

Is the augmentation and induction service meeting the standard of the licensed dose and dilution, is your regime/policy safe, sound and empowering to women service users?

Here are some of the questions that we have asked, please contact us for further detailed information or help with your regime or guideline.

What is the licensed therapeutic maximum licensed dose of synthetic oxytocin?

Maximum Licensed dose is 20 mU/MIN FOR LIVE Pregnancy.

What is the licensed dilution and dose for Intravenous Infusion?

Please check the instructions in your box of oxytocin ampoules, because that will be the licensed product. At the time of writing this, 2nd November 2017, you will find that it states that the licensed dose and dilution is - 5 iU oxytocin added to 500 ml of physiological electrolyte solution such as 0.9% Nsaline.


For patients who cannot have 0.9% Nsaline, 5% Dextrose can be used as an alternative diluent. Mix the solution well by turning the bag or bottle upside down several times.


Motorised pumps deliver smaller volumes than drip infusions and differ in their specification in terms of minimum volume delivery.

For motorised pumps one needs to consider the minimum volume which the pump delivers in order to calculate the correct dose and dilution (Please see the chart provided for motorised pumps in the download section below)


The starting dose is between 1- 4 mU per minute (2-8 drops per minute for drip infusion) with not less than 20 minutes interval apart. The increments not exceeding 1 - 2 mU per minute until a pattern of uterine contraction similar to that of a normal labour is established. In a term pregnancy, labour can be achieved with less than 10 mU/min (20 drops per minute for drip infusion).


Intravenous oxytocin use for foetal intra uterine death requires higher doses - 10 IU oxytocin added to 500 ml physiological electrolyte. The reason why one needs a higher dose is that the pregnancy may be premature and the uterus is less sensitive to oxytocin when the pregnancy is not at term.

Does giving the licensed increments, dose and dilution improve outcomes for women and their babies?

Yes, the licensed use acknowledges that this is a pain inducing hormone, that gently nudges a woman into labour, and harnesses her own natural oxytocin, and prompts her own endorphins into action. Over-dosage with synthetic oxytocin has inherent problems such as complication of hyper-stimulation of the uterus, foetal distress and its interventions.


These are avoided by using the licensed dosage range appropriately thus obtaining better outcomes. Overdosage dulls the uterine oxytocin receptors, and can cause uterine atony which predisposes to postpartum haemorrhage.

Is the licensed dose, dilution and increments of the pain inducing synthetic oxytocin being offered in the UK and globally?

This question will be answered later.

What is the purpose of the bolus button on the motorised pump, during an intravenous oxytocin infusion?

Synthetic oxytocin is known to be a pain inducing hormone. Therefore, the use of a bolus button on a pump is cruel and unnecessary and should immediately be disabled permanently when oxytocin is being used for infusion during augmentation and induction.

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